summary: Regular physical activity, especially strength training, can delay the onset of Alzheimer’s disease.
Using a mouse model, the researchers demonstrated that markers of Alzheimer’s disease, such as beta-amyloid plaques, were reduced and stress hormone levels normalized after resistance exercise training. Resistance training not only provides physical benefits, but also appears to reduce behavioral problems associated with Alzheimer’s disease.
This study advocates the introduction of resistance training as an affordable treatment for people with Alzheimer’s disease.
- Researchers have found that resistance training can delay the onset of Alzheimer’s disease symptoms, serving as a cost-effective treatment option.
- This study demonstrated that resistance training reduced the formation of beta-amyloid plaques, a key hallmark of Alzheimer’s disease, in a transgenic mouse model.
- Resistance training also helped reduce behavioral problems often associated with Alzheimer’s disease, such as hyperactivity, thereby improving the overall health of the subjects.
Regular physical exercise, such as resistance training, can prevent Alzheimer’s disease, or at least delay the onset of symptoms, and can serve as an easy and affordable treatment for people with Alzheimer’s disease.
This is the conclusion of an article published in Frontiers of Neuroscience By Brazilian researchers at the Federal University of Sao Paulo (UNIFESP) and the University of Sao Paulo (USP).
Older people and people with dementia are less likely to perform long daily runs or other high-intensity aerobic exercise, but these activities have been the focus of most scientific research on Alzheimer’s disease. increase.
The World Health Organization (WHO) recommends resistance exercise as the best option for developing balance, improving posture and preventing falls.
Resistance exercise involves contraction of specific muscles against external resistance and is considered an essential strategy for increasing muscle mass, strength and bone density, and for improving overall body composition, functional capacity and balance. increase.
It also helps prevent or reduce sarcopenia (muscle wasting) and makes it easier to perform daily activities.
To observe the neuroprotective effects of this practice, researchers from the Departments of Physiology and Psychobiology at UNIFESP and from the Department of Biochemistry at the USP Institute for Chemistry (IQ-USP) were involved in the accumulation of β-amyloid. Experiments were performed with transgenic mice carrying the mutation. Plaques in the brain.
This protein accumulates in the central nervous system, damaging synaptic connections and damaging neurons. All of these are hallmarks of Alzheimer’s disease.
In this FAPESP-funded study, mice were trained to climb a 110-cm ladder with an 80-degree incline and 2-cm steps. Loads corresponding to 75%, 90% and 100% of body weight were attached to the tail. The experiment mimicked a specific type of strength training performed by humans in a fitness center.
At the end of the 4-week training period, blood samples were taken to measure plasma levels of corticosterone, the mouse hormone equivalent to human cortisol. Elevated levels in response to stress increase the risk of developing Alzheimer’s disease.
Exercise-trained mice had normal hormone levels (same as those seen in a control group of non-mutated animals), and analysis of brain tissue showed reduced beta-amyloid plaque formation. .
“This confirms that physical activity can reverse the neuropathological changes that drive the clinical manifestations of the disease,” said Enrique Correia Campos, lead author of the paper.
“We also observed animal behavior to assess animal anxiety in the open field test. [which measures avoidance of the central area of a box, the most stress-inducing area] And we found that resistance exercise reduced hyperlocomotion in mice with a phenotype associated with Alzheimer’s disease to levels similar to controls,” said co-first author of the paper, IQ-USP Neuroscience. said Deidian Elisa Ribeiro, a researcher at the institute.
Agitation, restlessness, and wandering are common early symptoms of Alzheimer’s disease and other types of dementia.
“Resistance exercise is increasingly proving to be an effective strategy to avoid the emergence of sporadic Alzheimer’s disease symptoms. [not directly caused by a single inherited genetic mutation]It is multifactorial, may be associated with aging, and may delay the emergence of familial Alzheimer’s disease.
“The main possible reason for this effect is the anti-inflammatory action of resistance exercise,” said Beatriz Monteiro Longo, the last author of the paper and professor of neurophysiology at UNIFESP.
This animal model study Frontiers of NeuroscienceThe same group at UNIFESP summarized clinical evidence that the benefits of resistance exercise included positive effects on cognitive impairment, memory impairment, and behavioral problems in people with Alzheimer’s disease, making it an affordable alternative or adjunctive therapy. concluded that he would get
Researchers from Brazil’s Federal University of Rio Grande Norte (UFRN) and Ouro Preto Federal University (UFOP) also participated in the study.
“Alzheimer’s disease doesn’t just affect patients. It affects whole families, especially low-income families,” said UNIFESP graduate student Caroline Vieira Azevedo, lead author of the review paper.
“Both articles provide information that can be used to facilitate the development of public policy.
About this exercise and Alzheimer’s research news
author: Joan Silva
contact: Joao Silva – FAPESP
image: Image credited to Neuroscience News
Original research: open access.
“Neuroprotective effects of resistance exercise on the APP/PS1 mouse model of Alzheimer’s disease,” Henrique Correia Campos et al. Frontiers of Neuroscience
Neuroprotective effects of resistance exercise on the APP/PS1 mouse model of Alzheimer’s disease
Introduction: Physical exercise has beneficial effects by providing neuroprotective and anti-inflammatory responses against Alzheimer’s disease. However, most studies have been performed on aerobic exercise, and few studies have investigated the effects of other therapies that show positive effects on AD, such as resistance exercise (RE).
In addition to its benefits in the development of muscle strength, balance and muscle endurance leading to improved quality of life in older adults, RE has been shown to reduce amyloid burden and local inflammation, promote improved memory and cognition, and prevent degeneration as it occurs. Protects cortex and hippocampus. in advertising. Similar to AD patients, a double-transgenic APPswe/PS1dE9 (APP/PS1) mouse exhibits her Aβ plaques, hyperkinesia, memory impairment, and exacerbated inflammatory responses in the cortex and hippocampus.
Therefore, the aim of this study was to investigate the effect of 4-week intermittent RE training on the prevention and recovery of these AD-related neuropathological conditions in APP/PS1 mice.
Method: For this purpose, mutation (CTRL)-negative 6- to 7-month-old male APP/PS1 transgenic mice and their littermates were divided into three groups: CTRL, APP/PS1, and APP/PS1+RE. bottom. RE training lasted for 4 weeks, and at the end of the program an open field test for the animals’ motor activity and an object recognition test for assessment of recognition memory were performed. Brains were collected for immunohistochemical analysis of Aβ plaques and microglia, and blood was collected for plasma corticosterone by ELISA assay.
result: In an open field study, APP/PS1 transgenic sedentary mice exhibited increased hippocampal Aβ plaques and elevated plasma corticosterone levels, as well as hyperlocomotion compared to APP/PS1-exercised and control animals. and showed a reduction in median transversal. An intermittent program of RE was able to restore behavioral, corticosterone and Aβ changes to her CTRL levels. Furthermore, the RE protocol increased the number of microglial cells within the hippocampus of APP/PS1 mice. Despite these changes, no memory deficits were observed in APP/PS1 mice in novel object recognition tests.
Discussion: Taken together, our results suggest a role for RE in reducing AD symptoms and highlight the beneficial effects of RE training as a complementary treatment for AD.
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